ea0070aep585 | Pituitary and Neuroendocrinology | ECE2020
Abbara Ali
, Chia Eng Pei
, Phylactou Maria
, Clarke Sophie
, Mills Edouard
, Chia Germaine
, Yang Lisa
, Izzi-Engbeaya Chioma
, Jayasena Channa
, Comninos Alexander
, Ivell Richard
, Anand-Ivell Ravinder
, Rademaker Jesse
, Cheng Xu
, Quinton Richard
, Pittelout Nelly
, Dhillo Waljit
Background: Hypogonadotrophic hypogonadism is characterised by hypogonadism in the context of low/inappropriately normal gonadotrophin levels. Congenital Hypogonadotrophic Hypogonadism (CHH) occurs due to disrupted GnRH neuronal migration, or impaired hypothalamic GnRH secretion or action. However, no direct test of hypothalamic GnRH neuronal function currently exists. Kisspeptin-54 is a neuropeptide that stimulates endogenous hypothalamic GnRH release. Thus, we investigated w...